Accelerator mass spectrometry in biomedicine

A variety of complementary techniques have been used in connection with accelerator mass spectrometry in the field of biomedicine, facilitating extreme measurement capabilities. A number of new interdisciplinary research areas have subsequently been developed, with unique analytical capabilities. Examples are:

Sensitivity In pharmacology, we have demonstrated detection of 14C-marked drugs in human blood in the zeptomole level range (1 Zeptomole=10-21 mole).

Small samples Microdosing (clinical phase 0 trials). New drug candidates can be administered directly to human subjects at an early stage to extract important pharmacokinetic data. This provides information on how the drug is absorbed, distributed, metabolized and excreted.

Regenerative medicine In a long term collaborative work with Karolinska Institutet we have developed a method to study specific cell types and extract neurogenesis rates for various parts of the human brain, previously not possible.

Forensic Sciences In collaboration with the law authorities, date of birth and death can be determined for samples such as teeth from deceased individuals.

Selected publications

O. Bergmann, S. Zdunek, A. Felker, M. Salehpour et al.
Dynamics of Cell Generation and Turnover in the Human Heart
Cell 161 (2015) 1566

Arner, P, Bernard, S, Salehpour, M, Possnert, G, et al.
Dynamics of human adipose lipid turnover in health and metabolic disease
Nature 478 (2011) 110-113

A. Ernst, K. Alkass, S. Bernard, M. Salehpour, S. Perl, J. Tisdale, G. Possnert, H. Druid, J. Frisén
Neurogenesis in the Striatum of the Adult Human Brain
Cell 156 (2014) 1072

Spalding, K., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M. et al.
Dynamics of Hippocampal Neurogenesis in Adult Humans
Cell 153 (2013) 1219-1227

S. Hägg, M. Salehpour, P. Noori, J. Lundström, G. Possnert, et al.
Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin
PLoS ONE 6(2011) e18248

Salehpour, Possnert, Bryhni
Subattomole sensitivity in biological accelerator mass spectrometry
Analytical Chemistry 80 (2008) 3515

A. Persson, M. Berglund, G. Thornell, G. Possnert and M. Salehpour
Stripline split-ring resonator with integrated optogalvanic sample cell
Laser Physics Letters 11 (2014) 045701

Last modified: 2022-06-07