Postdoc position in Serial Femtosecond Crystallography
The Department of Physics and Astronomy at Uppsala University is announcing a two-year post doctoral position starting in 2019.
The project is “Serial Femtosecond Crystallography – from nanocrystals to nanoplasma in a flash” that will study the diffraction before destruction of protein crystals with X-ray lasers, using theoretical models and/or experimental measurements.
Serial Femtosecond Crystallography (SFX) has opened a new avenue for determining atomic structure of biomolecules with X-rays. It circumvents the conflicting requirement of intense X-rays needed for high resolution and low radiation dose needed to minimize damage. SFX employs extremely short and intense X-ray laser pulses that permit interpretable diffraction patterns to be recorded from a serial flashing of randomly oriented crystals, which flow in a water jet, before each sample is destroyed. We plan to study the ultrafast transition from nanocrystals to nanoplasma, and use theoretical models (molecular dynamics, plasma simualtions, crystallographic software) to improve the achievable resolution by correcting for the loss of coherence during exposure.
Members of the biophysics research group are Nicusor Timneanu and Carl Caleman at the Department of Physics and Astronomy, in close collaboration with Henry Chapman and Thomas White from the Coherent Imaging Division at the Center for Free Electron Laser Science in Hamburg. For information about both groups, see http://www.physics.uu.se/research/biophysics-initiative/ and https://cid.cfel.de/
Candidates must have a doctoral degree in Physics or equivalent, obtained no more than three years prior to the application deadline. Experience in X-ray science, protein crystallography, crystallographic software, computing simulations are preferable.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and even gender balance, and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
The postdoc is based on a a scholarship grant from Carl Trygger Foundation, and there are also funds for travel and computer resources.
The application should consist of a letter of intent including a research statement, CV, list of publications, and two reference letters.
Deadline for application – 2018-05-15
Starting date – no later than 2019-09-01
Department of Physics and Astronomy
SE-751 20 Uppsala